Table 2. List of prioritisation criteria grouped by domain
Criterion	Explanation
	Domain 1. Population/end-users
Frequency of use	When it is known or envisaged that the technology may be applied to a large number of patients.
Disease burden	The condition or indication for which the technology is being used entails elevated mortality, morbidity, disability or affects the patient’s quality of life to a major extent..
Impact on end-user/population	The technology may bring about important improvements in the state of health/wellbeing of the subjects or population to which it is applied (e.g., population screening).
Vulnerable populations	The technology has been designed to be fundamentally used on a highly sensitive group (e.g., pregnant women, chronically ill patients).
	Domain 2. Technology
Innovative technology	Where the design, materials or their operation are totally new or very different to other already existing technologies and/or there are no previous technological alternatives for this clinical indication.
Invasive technology	Any technology that requires surgical intervention or aggressive medical procedure for its use. This also includes implantable devices or systems designed to be introduced, wholly or in part, into the human body, with the intention that these are to remain there post-procedure.
Different expectations of use	The health technology may be open to having different applications in clinical practice and being used in clinical indications other than those approved.
Criterion	Explanation
	Domain 3. Safety/adverse effects
Safety	There is evidence in the literature of adverse effects and/or it is envisaged that these may occur, due to the existence of adverse effects with similar technologies or procedures.
Undetected potential adverse effects	The available evidence is deemed insufficient for supplying information on infrequent adverse effects. Studies include a small number of patients overall or for given subgroups, and/or the study follow-up period is short for the purpose of adequately assessing the appearance of medium-/long-term adverse effects.
Risks	There is the possibility that health staff may suffer harm as a consequence of its use (e.g., radiation) or it poses an environmental hazard (e.g., dangerous waste).
	Domain 4. Organisation/costs and other implications
Need for training	Technologies which require an intense period of training and the results of which may, in great measure, depend on knowledge acquired and personal abilities (learning curve).
Financial impact	Necessary investment in infrastructure, equipment and/or cost of fungible goods, maintenance or human resources.
Organisational or structural impact	Technologies that demand multidisciplinarity, creation of new units, co-ordination among different units, or creation of specific units.
Other implications	It is envisaged that the technology may have an important impact on the ethical, social, cultural and/or legal sphere